Our Research
The Miller Lab in the Center for Public Health Genomics at the University of Virginia focuses on integrating large-scale human genetics and genomics datasets with clinically relevant functional models. We employ an array of bioinformatics approaches and phenotypic screens using both genetic and drug perturbations to investigate causal mechanisms at candidate loci.
Our primary goals are to:
- Understand fundamental vascular biology and disease regulatory mechanisms.
- Identify new targets or risk factors for complex cardiovascular diseases.
- Investigate role of candidate genes on vascular wall processes using preclinical and repositioned therapeutics.
Recent Projects
News
Congratulation to Gaelle and Clint for their contribution to this study on rare variants
in collaboration with Ron Do and colleagues. Rare variant contribution to the heritability of coronary artery disease See media coverage HERE
Congrats to Clint for his collaborative awards !
Genome Sciences Faculty Awarded $2.9 Million to Identify Molecular Drivers of Atherosclerosis in Diabetes This funding from NIH/NIDDK allows to launch a network in collaboration with Mete Civelek, Suna Onengut, and Sander W. van der Laan and plans on applying multi-omic single-cell and spatial approaches to identify molecular drivers of ...
The Center for Public Health Genomics transition to the Department of Genome Sciences (DGS)
Announcing the New Department of Genome Sciences
Congratulations to Clint and the lab for their award
Clint Miller, PhD, Awarded $2.8 Million NHLB Grant to Research Coronary Artery Disease
Chani Hodonsky’s paper is featured in UVAHealth Newsroom
UVA Getting to Heart of Coronary Artery Disease
Congrats to Chani Hodonsky on her first author manuscript published in Cell Genomics!
Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci