Rocheleau G, Clarke SL, Auguste G, [...] Miller CL, [...] Do R. Rare variant contribution to the heritability of coronary artery disease. Nature Communications 2024, Oct 9;15(1):8741. doi: 10.1038/s41467-024-52939-6.
Pirri D, Tian S, Tardajos-Ayllon B, [...] Miller CL, [...] Evans PC. Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake. Circulation Research 2024 Sep 27;135(8):822-837. doi: 10.1161/CIRCRESAHA.123.324054.
Bell CF, Baylis RA, Lopez NG, Ma WF, Gao H, Wang F, Bamezai S, Fu C, Kojima Y, Adkar SS, Luo L, Miller CL, Leeper NJ. BST2 induces vascular smooth muscle cell plasticity and phenotype switching during cancer progression. bioRxiv . 2024 Sep 14:2024.09.10.612298.
Noordam R, Wang W, Nagarajan P, [...] Clint L Miller, [...] Diana van Heemst. A Large-Scale Genome-Wide Gene-Sleep Interaction Study in 732,564 Participants Identifies Lipid Loci Explaining Sleep-Associated Lipid Disturbances. medRxiv 2024 Sep 4:2024.09.02.24312466.
Xu J, Liu Z, Yang Q, [...] Miller CL, Malhotra R, Weintraub NL, Huo Y. Adenosine kinase inhibition protects mice from abdominal aortic aneurysm via epigenetic modulation of VSMC inflammation. Cardiovascular Research 2024 Sep 2;120(10):1202-1217
Geurts S, Tilly MJ, Lu Z, S[...] Miller CL, Ikram MA, Kavousi M. Antihypertensive Drugs for the Prevention of Atrial Fibrillation: A Drug Target Mendelian Randomization Study. Hypertension. 2024, August;81(8):1766-1775.
Salido E, de Medeiros Vieira C, Mosquera JV, Zade R, Miller CL, Lo Sardo V. The 9p21.3 coronary artery disease risk locus drives vascular smooth muscle cells to an osteochondrogenic state. bioRxiv 2024, July 20:2024.05.25.595888.
Wang H, Nagarajan P, Winkler T, Bentley A, Miller C, Kraja A, A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations. Res Sq 2024 July 17:rs.3.rs-4163414.
Mori M, Sakamoto A, Kawakami R, [...] Mosquera JV, [...] Miller CL, Virmani R, Finn AV. CD163+ Macrophages Induce Endothelial-to-Mesenchymal Transition in Atheroma. Circulation Research 2024 July 5;135(2):e4-e23.
Mocci G, Sukhavasi K, Örd T, Bankier S,[...] Hodonsky CJ, [...] Miller CL [...] Björkegren JLM.Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis.Circulation Research 2024 May 24;134(11):1405-1423<
Lu H, Lary CW, Hodonsky CJ, [...] van der Laan SW, Miller CL, [...] Medina-Gomez C. Association between BMD and coronary artery calcification: an observational and Mendelian randomization study. Journal of Bone and Mineralization Research. 2024 May 2;39(4):443-452
Nagarajan P, Winkler TW, Bentley AR, Miller CL, [...] Wang H. A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations. medRxiv 2024 March 8;2024.03.07.24303870.
Hodonsky CJ, Turner AW, Khan MD, Barrientos NB, Methorst R, Ma L, Lopez NG, Mosquera JV, Auguste G, Farber E, Ma WF, Wong D, Onengut-Gumuscu S, Kavousi M, Peyser PA, van der Laan SW, Leeper NJ, Kovacic JC, Björkegren JLM, Miller CL. Cell Genomics . 2024 Jan 10;4(1):100465.
Cornelissen A, Gadhoke NV, Ryan K, Hodonsky CJ, [...] Miller CL, [...] Finn AV. Polygenic Risk Score Associates With Atherosclerotic Plaque Characteristics at Autopsy. Arteriosclerosis, Thrombosis, and Vascular Biology . 2024 Jan;44(1):300-313.
Mosquera JV, Auguste G, Wong D, Turner AW, Hodonsky CJ, Alvarez-YelaLino AC, Song Y, Cheng Q, Cardenas CL, Theofilatos K, Bos M, Kavousi M, Peyser P, Mayr M, Kovacic JC, Bjorkegren JLM, Malhotra R, Stukenberg T, Finn AV, van der Laan SW, Zang C, Sheffield NC, Miller CL. Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis. Cell Reports 2023, November 28, Volume 42, Issue 11113380
Cornelissen A, Gadhoke NV, Ryan K, Hodonsky CJ, [...] Miller CL, Hong CC, Grove ML, Brody JA, Sotoodehnia N, Arking DE, Schunkert H, Mitchell BD, Guo L, Virmani R, Finn AV. Polygenic Risk Score Associates with Atherosclerotic Plaque Characteristics at Autopsy. Arteriosclerosis, Thrombosis, and Vascular Biology 2023, November 2;Volume 44, Number 1
Mekke JM, Sakkers TR, Verwer MC, [...] Song Y, Miller CL, [...] van der Laan SW. The accumulation of erythrocytes quantified and visualized by Glycophorin C in carotid atherosclerotic plaque reflects intraplaque hemorrhage and pre-procedural neurological symptoms. Scientific Reports. 2023, October 10, Volume 13, Article number: 17104.
Kavousi M, Bos MM, Barnes HJ, Lino Cardenas CL, Wong D, Lu H, Hodonsky CJ, Landsmeer LPL,Turner AW, Minjung Kho M, Hasbani NR, de Vries PS, Bowden DW, Chopade S, Deelen J, Benavente ED, Guo X, Hofer E, Hwang SJ, Lutz SM, Lyytikäinen LP, Slenders L, Smith AV, Stanislawski MA, van Setten J, Wong Q, Yanek LR, Becker DM, Beekman M, Budoff MJ, Feitosa MF, Finan C, Hilliard AT, Kardia SLR, Kovacic JC, Kral BG, Langefeld CD, Launer LJ, Malik S, Hoesein FAAM, Mokry M, Schmidt R, Smith JA, Taylor KD, Terry JG, van der Grond J, van Meurs J, Vliegenthart R, Xu J, Young KA, Zilhão NR, Zweiker R, Assimes TL 44, Becker LC, Bos D, Carr JJ, Cupples LA, P V de Kleijn DPV, de Winther M, den Ruijter HM, Fornage M, Freedman BI, Gudnason V, Hingorani AD, Hokanson JE, Ikram MA, Išgum I, Jacobs Jr DR, Kähönen M, Lange LA, Lehtimäki T, Pasterkamp G, Raitakari OT, Schmidt H, Slagboom PE, Uitterlinden AG, Vernooij MW, Bis JC, Franceschini N, Psaty BM, Post WS, Rotter JI, Björkegren JLM, O'Donnell CJ, Bielak LF, Peyser PA, Malhotra R, van der Laan SW, Miller CL Multi-ancestry genome-wide analysis identifies effector genes and druggable pathways for coronary artery calcification. Nature Genetics. 2023, Sept 28, 55(10):1651-1664.
von Scheidt M, Bauer S, Ma A, [...] Hodonsky CJ, [..] Miller CL, [...] Schunkert H. Leukocytes carrying Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations invade Human Atherosclerotic Plaques. medRxiv. 2023 Jul 26:2023.07.22.23292754.
Zhang W, Zhao J, Deng L, Ishimwe N, Pauli J, Wu W, Shan S, Kempf W, Ballantyne MD, Kim D, Lyu Q, Bennett M, Rodor J, Turner AW, Lu YW, Gao P, Choi M, Warthi G, Kim HW, Barroso MM, Bryant WB, Miller CL, Weintraub NL, Maegdefessel L, Miano JM, Baker AH, Long X. INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10. Circulation. 2023 July 4;148(1):47-67.
Safabakhsh S, Ma WF, Miller CL, Laksman Z. Cardiovascular utility of single cell RNA-Seq. Current Opinion in Cardiology. 2023, May, 38(3):p 193-200
Zheng J, Wheeler E, Pietzner M, [...] Miller CL, [...] Tobias JH. Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization Arthritis & Rheumatology 2023, April 25
Wong D, Auguste G, Lino Cardenas CL, Turner AW, Chen Y, Song Y, Ma L, Perry RN, Aherrahrou R, Kuppusamy M, Yang C, Mosquera JV, Dube CJ, Khan MD, Palmore M, Kalra J, Kavousi M, Peyser PA, Matic L, Hedin U, Manichaikul A, Sonkusare SK, Civelek M, Kovacic JC, Björkegren JLM, Malhotra R, Miller CL. FHL5 Controls Vascular Disease–Associated Gene Programs in Smooth Muscle Cells Circulation Research 2023, April 5; Volume 132, Number 9.
Song Y, Cisternino F, Mekke JM, de Borst G, de Kleijn DPV, Pasterkamp G, Vink A, Glastonbury CA, van der Laan SW, Miller CL. An automatic entropy method to efficiently mask histology whole-slide images Scientific Reports 2023, March 15;Volume 13, Article number: 4321
Zhang M, Li J, Wang Q, Urabe G, Tang R, Huang Y, Mosquera JV, Kent KC, Wang B, Miller CL, Guo LW. Gene-repressing epigenetic reader EED unexpectedly enhances cyclinD1 gene activation. Mol Ther Nucleic Acids. 2023, MArch 14;Volume 31,p717-729.
Aherrahrou R, Lue D, Perry RN, [...] Khan MD, [...] Miller CL, [...] Civelek M. Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes. Circulation Research. 2023, February 3;132(3):323-338.
Zhang W, Zhao J, Deng L, Ishimwe N, [...] Turner AW, [...] Miller CL, [...] Long X. INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10. Circulation. 2023, May 18; Volume 148, Number 1.
Sakamoto A, Kawakami R, Mori M, Guo L, Paek KH, Mosquera JV, Cornelissen A, Ghosh SKB, Kawai K, Konishi T, Fernandez R, Fuller DT, Xu W, Vozenilek AE, Sato Y, Jinnouchi H, Torii S, Turner AW, Akahori H, Kuntz S, Weinkauf CC, Lee PJ, Kutys R, Harris K, Killey AL, Mayhew CM, Ellis M, Weinstein LM, Gadhoke NV, Dhingra R, Ullman J, Dikongue Emene EA, Romero ME, Kolodgie FD, Miller CL, Virmani R, Finn AV. CD163+ macrophages restrain vascular calcification, promoting the development of high-risk plaque. JCI Insight. 2023, January 31; e154922.
Mokry M, Boltjes A, Cui K, [...] Turner AW, Khan MD, Hodonsky CJ, [...] Miller CL, Pasterkamp G. Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation. Nature Cardiovascular Research. 2022, December 12; 1140–1155.
Ma WF, Turner AW, Gancayco C, Wong D, Song Y, Mosquera JV, Auguste G, Hodonsky CJ, Prabhakar A, Ekiz HA, van der Laan SW, Miller CL. PlaqView 2.0: A comprehensive web portal for cardiovascular single-cell genomics. Frontiers in Cardiovascular Medicine. 2022, August 8; 9:969421.
Wang Y, Gao H, Wang F, [...] Turner AW, [...] Miller CL, Ross EG, Leeper NJ. Dynamic changes in chromatin accessibility are associated with the atherogenic transitioning of vascular smooth muscle cells. Cardiovascular Research. 2022,October 21; 118(13):2792-2804.
Ma L, Bryce NS, Turner AW, [...] Miller CL, Björkegren JLM, Kovacic JC. The HDAC9-associated risk locus promotes coronary artery disease by governing TWIST1. PLoS Genetic. 2022, Jun2 17; 18(6):e1010261.
Turner AW, Hu SS, Mosquera JV, Ma WF, Hodonsky CJ, Wong D, Auguste G, Song Y, Sol-Church K, Farber E, Kundu S, Kundaje A, Lopez NG, Ma L, Ghosh SKB, Onengut-Gumuscu S, Ashley EA, Quertermous T, Finn AV, Leeper NJ, Kovacic JC, Björkgren JLM, Zang C, Miller CL. Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk. Nature Genetics. 2022 June; 54(6):804-816.
Lino Cardenas CL, Jiang W, Cherbonneau F, [...] Miller CL, Malhotra R. Novel treatment of small and large artery calcific disease via epigenetic activation of autophagy initiation genes. Research Square. 2022.05.03.
Slenders L, Landsmeer LPL, Cui K, [...] Ma WF, Miller CL, [...] Mokry M. Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis. Eur Heart J Open. 2021 Dec 21;2(1):oeab043.
Ma WF, Hodonsky CJ, Turner AW, Wong D, Song Y, Mosquera JV, Ligay AV, Slenders L, Gancayco C, Pan H, Barrientos NB, Mai D, Alencar GF, Owsiany K, Owens GK, Reilly MP, Li M, Pasterkamp G, Mokry M, van der Laan SW, Khomtchouk BB, Miller CL. Enhanced single-cell RNA-seq workflow reveals coronary artery disease cellular cross-talk and candidate drug targets. Atherosclerosis. 2022, January 12, 340.
Read moreHao K, Ermel R, Sukhavasi K, [...] Miller CL, [...] Kovacic JC. Integrative Prioritization of Causal Genes for Coronary Artery Disease. Circulation: Genomic and Precision Medicine. 2021, December 28, Volume 15, Number 1.
Aguilar-Pineda JA, Vera-Lopez KJ, Shrivastava P, [...] Miller CL, [...] Lino Cardenas CL. Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease. iScience. 2021 August 19;24(9):102993.
Drake JC, Wilson RJ, Laker RC, [...] Miller CL, [...] Yan Z. Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy. Proc Natl Acad Sci USA. 2021 Sep 14;118(37):e2025932118.
Mekke JM, Sakkers TR, Verwer MC, [...] Song Y, Miller CL, [...] van der Laan SW. Glycophorin C in atherosclerotic plaque is associated with major adverse cardiovascular events after carotid endarterectomy. medRxiv 2021.07.15.21260570.
Miller CL, Zhang H. Clarifying the Distinct Roles of Smooth Muscle Cell-Derived Versus Macrophage Foam Cells and the Implications in Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 2021 Jun;41(6):2035-2037.
Cornelissen A, Fuller DT, Fernandez R, [...] Miller CL, [...], Finn AV. APOL1 Genetic Variants Are Associated With Increased Risk of Coronary Atherosclerotic Plaque Rupture in the Black Population. Arteriosclerosis, Thrombosis, and Vascular Biology. 2021 May 27:ATVBAHA120315788.
Miller CL, Kontorovich AR, Hao K, [...] Kovacic JC. Precision Medicine Approaches to Vascular Disease: JACC Focus Seminar 2/5. J Am Coll Cardiol. 2021 May 25;77(20):2531-2550.
Hartiala JA, Han Y, Jia Q, [...] Turner AW, Miller CL, [...] Allayee H. Genome-wide analysis identifies novel susceptibility loci for myocardial infarction. Eur Heart J. 2021 Mar 1;42(9):919-933.
Read moreAherrahrou R, Guo L, Nagraj VP, [...] Miller CL, [...] Civelek M. Genetic Regulation of Atherosclerosis-Relevant Phenotypes in Human Vascular Smooth Muscle Cells. Circulation Research. 2020 Dec 4;127(12):1552-1565.
Wang Y, Nanda V, Direnzo D, [...] Miller CL, [...] Leeper NJ. Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade. Proc Natl Acad Sci USA. 2020 Jul 7;117(27):15818-15826.
Kessler MD, Loesch DP, Perry JA, [...]; National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Population Genetics Working Group, O'Connor TD. De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population. Proc Natl Acad Sci USA. 2020 Feb 4;117(5):2560-2569.
Rykaczewska U, Suur BE, Röhl S, [...] Miller CL, [...] Matic L. PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling. Circulation Research. 2020 Feb 28;126(5):571-585.
Read moreWirka RC, Wagh D, Paik DT, [...], Miller CL, [...] Quertermous T. Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis. Nature Medicine. 2019 Aug;25(8):1280-1289.
Xu S, Xu Y, Liu P, [...], Miller CL, Jin ZG. The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis. European Heart Journal. 2019 Aug 1;40(29):2398-2408.
Jaffré F, Miller CL, Schänzer A, [...] Kontaridis MI.iPSC-Derived Cardiomyocytes Reveal Aberrant ERK5 and MEK1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome. Circulation. 2019 Jul 16;140(3):207-224.
Wong D, Turner AW, Miller CL.Genetic Insights Into Smooth Muscle Cell Contributions to Coronary Artery Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 2019 Jun;39(6):1006-1017.
Zhao Q, Wirka R, Nguyen T, [...] Miller CL [...] Quertermous T.TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression. Genome Medicine. 2019 May 2;11(1):23.
Turner AW, Wong D, Khan MD, Dreisbach CN, Palmore M, Miller CL.Multi-Omics Approaches to Study Long Non-coding RNA Function in Atherosclerosis. Frontiers in Cardiovascular Medicine. 2019 Feb 19;6:9.
Read moreNanda V, Wang T, Pjanic M, [...] Miller CL. Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus. PLoS Genetics. 2018 Nov 16;14(11):e1007755.
Iyer D, Zhao Q, Wirka R, [...] Miller CL [...] Quertermous T. Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk. PLoS Genetics. 2018 Oct 11;14(10):e1007681.
Liu B, Pjanic M, Wang T, [...] Miller CL, Quertermous T. Genetic Regulatory Mechanisms of Smooth Muscle Cells Map to Coronary Artery Disease Risk Loci. American Journal of Human Genetics. 2018 Sep 6;103(3):377-388.
Turner AW, Wong D, Dreisbach CN, Miller CL. GWAS reveal targets in vessel wall pathways to treat coronary artery disease. Frontiers in Cardiovascular Medicine. 2018 Jun 25;5:72.
Wang Z, Civelek M, Miller CL, Sheffield NC, Guertin MJ, Zang C. BART: a transcription factor prediction tool with query gene sets or epigenomic profiles. Bioinformatics. 2018 Aug 15;34(16):2867-2869.
Kojima Y, Werner N, Ye J, [...] Miller CL, [...] Leeper NJ. Proefferocytic Therapy Promotes Transforming Growth Factor-β Signaling and Prevents Aneurysm Formation. Circulation. 2018 Feb 13;137(7):750-753.
Read moreMatic L, Rykaczewska U, Rohl S, [...] Miller CL, [...] Paulsson-Berne G. PCSK6 is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling. Journal of Vascular Research. 2017 Jan 1;54:22-22.
Kim JB*, Pjanic M*, Nguyen T, Miller CL, [...] Quertermous T. TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells. PLoS Genetics. 2017 May 8;13(5):e1006750.
Read moreMiller CL and Leeper NJ. GWAS candidate gene to dual modifier of non-alcoholic fatty liver disease and atherosclerosis. Journal of the American College of Cardiology: Basic to Translational Science. 2016.
Pjanic M, Miller CL, Wirka R, [...] Quertermous T. Genetics and genomics of coronary artery disease. Current Cardiology Reports. 2016. Oct;18(10):102.
Perisic L, Rykaczewska U, Razuvaev A, [...] Miller CL, [...] Hedin U. Phenotypic modulation of smooth muscle cells in atherosclerosis is associated with downregulation of LMOD1, SYNPO2, PDLIM7, PLN and SYNM. Arteriosclerosis, Thrombosis and Vascular Biology. 2016 Sep;36(9):1947-61.
Kojima Y, Volkmer JP, McKenna K, [...] Miller CL, [...] Leeper NJ. CD47 blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature. 2016 Aug 4;536(7614):86-90.
Miller CL*, Pjanic M*, Wang T, [...] Quertermous T. Integrative functional genomics identifies regulatory mechanisms at coronary heart disease loci. Nature Communications. 2016 Jul 8;7:12092.
Read moreMiller CL*, Pjanic M*, Quertermous T. From locus association to mechanism of gene causality: the devil is in the details. Arteriosclerosis, Thrombosis and Vascular Biology. 2015 Oct;35(10):2079-80.
Nürnberg ST*, Cheng K*, [...] Miller CL, [...] Quertermous T. TCF21 regulates smooth muscle cell precursor cells that contribute to the fibrous cap. PLoS Genetics. 2015 May 28;11(5):e1005155.
Sazonova OV*, Zhao Y*, Nürnberg ST*, Miller CL, [...] Quertermous T. Characterization of TCF21 downstream target regions identifies a transcriptional pathway linking multiple independent coronary heart disease loci. PLoS Genetics. 2015 May 28;11(5):e1005202.
Miller CL, Haas U, Diaz R, [...] Quertermous T, Sczakiel G†. Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. PLoS Genetics . 2014 Mar 27; 10(3):e1004263.
Miller CL, Assimes TL, Montgomery SB, Quertermous T. Dissecting the causal genetic mechanisms of coronary heart disease. Current Atherosclerosis Reports. 2014 May;16(5):406.
Kojima Y, Downing KP, Kundu RK, Miller CL, [...] Leeper NJ. CDKN2B regulates efferocytosis and atherosclerosis. Journal of Clinical Investigation. 2014 Mar 3;124(3):1083-97.
Read moreMiller CL, Anderson DR, Kundu RK, [...] Quertermous T. Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus. PLoS Genetics 2013 Jul;9(7):e1003652.
Leeper NJ, Raiesdana A, Kojima Y, [...] Miller CL, [...] Quertermous T. Loss of CDKN2B promotes p53-dependent smooth muscle cell apoptosis and aneurysm formation. Arteriosclerosis, Thrombosis and Vascular Biology. 2013 Jan;33(1):e1-e10.
Read moreMiller CL, Oikawa M, Cai Y, [...] Yan C. Cyclic nucleotide phosphodiesterase 1: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. Basic Research in Cardiology. 2011 Nov;106(6): 1023-39.
Read moreCai Y, Miller CL, [...] Yan C. Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells. Arteriosclerosis, Thrombosis and Vascular Biology. 2010 Dec 9;31(3): 616-23.
Miller CL, Yan C. Targeting cyclic nucleotide phosphodiesterase in the heart: therapeutic implications. Journal of Cardiovascular Translational Research. 2010 Oct;3(5): 507-15.
Miller CL, Oikawa M, [...] Yan C. Role of Ca2+/CaM-stimulated phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. Circulation Research. 2009 Nov 6;105(10): 956-64.
Yan C, Miller CL, Abe J. Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart. Circulation Research. 2007 Mar 2;100(4): 489-501.
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